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David T MacLaughlin Selected Research

Anti-Mullerian Hormone

9/2012Mullerian inhibiting substance induces apoptosis of human endometrial stromal cells in endometriosis.
2/2012Human ovarian cancer stem/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance.
1/2011Mullerian inhibiting substance inhibits invasion and migration of epithelial cancer cell lines.
11/2010Mullerian inhibiting substance preferentially inhibits stem/progenitors in human ovarian cancer cell lines compared with chemotherapeutics.
3/2010Development of an efficiently cleaved, bioactive, highly pure FLAG-tagged recombinant human Mullerian Inhibiting Substance.
3/2007Mullerian-inhibiting substance induces Gro-beta expression in breast cancer cells through a nuclear factor-kappaB-dependent and Smad1-dependent mechanism.
11/2006Mullerian Inhibiting Substance enhances subclinical doses of chemotherapeutic agents to inhibit human and mouse ovarian cancer.
3/2006Recombinant human Mullerian inhibiting substance inhibits long-term growth of MIS type II receptor-directed transgenic mouse ovarian cancers in vivo.
1/2005Endometrial cancer is a receptor-mediated target for Mullerian Inhibiting Substance.
1/2005Metformin reduces serum mullerian-inhibiting substance levels in women with polycystic ovary syndrome after protracted treatment.
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David T MacLaughlin Research Topics

Disease

12Neoplasms (Cancer)
03/2017 - 01/2002
7Ovarian Neoplasms (Ovarian Cancer)
03/2017 - 12/2003
4COVID-19 related adult multisystem inflammatory disease
03/2010 - 01/2005
3Carcinoma (Carcinomatosis)
06/2012 - 03/2006
3Cryptorchidism (Undescended Testes)
02/2003 - 01/2002
2Endometrial Neoplasms (Endometrial Cancer)
05/2015 - 01/2005
2Endometriosis
09/2014 - 09/2012
2Ovarian Epithelial Carcinoma
09/2014 - 12/2003
2Uterine Cervical Neoplasms (Cancer of the Cervix)
06/2012 - 12/2003
2Persistent Mullerian duct syndrome
10/2003 - 01/2002
1Wounds and Injuries (Trauma)
03/2017
1Neoplasm Metastasis (Metastasis)
01/2011
1Granulosa Cell Tumor
07/2009
1Sex Cord-Gonadal Stromal Tumors (Sex Cord-Stromal Tumor)
06/2009
1Germ Cell and Embryonal Neoplasms (Germ Cell Tumor)
06/2009
1Breast Neoplasms (Breast Cancer)
03/2007
1Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal)
01/2005
1Leydig Cell Tumor
03/2004
1Disorders of Sex Development (Intersexuality)
02/2003
1Anorchia
08/2002
1Adenocarcinoma
01/2002
1Prostatic Neoplasms (Prostate Cancer)
01/2002
1Idiopathic Hypogonadotropic Hypogonadism
01/2002

Drug/Important Bio-Agent (IBA)

15anti-Mullerian hormone receptorIBA
05/2015 - 01/2002
14Anti-Mullerian HormoneIBA
09/2012 - 01/2002
6Hormones (Hormone)IBA
03/2017 - 03/2004
4Proteins (Proteins, Gene)FDA Link
03/2017 - 11/2006
4Biological ProductsIBA
06/2012 - 11/2006
4Messenger RNA (mRNA)IBA
06/2012 - 01/2002
3Transforming Growth Factor beta (TGF-beta)IBA
03/2010 - 01/2005
2Doxorubicin (Adriamycin)FDA LinkGeneric
02/2012 - 11/2006
2Epithelial Cell Adhesion MoleculeIBA
02/2012 - 11/2010
2Pharmaceutical PreparationsIBA
03/2010 - 03/2006
2Immunologic Factors (Immunomodulators)IBA
06/2009 - 01/2005
2NF-kappa B (NF-kB)IBA
03/2007 - 01/2002
2DNA (Deoxyribonucleic Acid)IBA
03/2004 - 01/2002
1CateninsIBA
03/2017
1Small Interfering RNA (siRNA)IBA
03/2017
1Recombinant ProteinsIBA
09/2014
1ThiazolesIBA
06/2012
1FITC-annexin A5IBA
06/2012
1Cyclin-Dependent Kinases (cdk Proteins)IBA
02/2012
1Surface Antigens (Surface Antigen)IBA
11/2010
1ChemokinesIBA
03/2007
1Cisplatin (Platino)FDA LinkGeneric
11/2006
1Paclitaxel (Taxol)FDA LinkGeneric
11/2006
1Sirolimus (Rapamycin)FDA Link
11/2006
1Growth InhibitorsIBA
03/2006
1Tumor Viral Antigens (Large T Antigen)IBA
03/2006
1Antineoplastic Agents (Antineoplastics)IBA
03/2006
1Glycoproteins (Glycoprotein)IBA
01/2005
1Cell Cycle ProteinsIBA
01/2005
1Metformin (Glucophage)FDA LinkGeneric
01/2005
1Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA
12/2003
1Gonadal HormonesIBA
02/2003
1Testosterone (Sustanon)FDA Link
08/2002
1AndrogensIBA
01/2002
1inhibin BIBA
01/2002
1Biomarkers (Surrogate Marker)IBA
01/2002
1Gonadotropin-Releasing Hormone (GnRH)FDA Link
01/2002

Therapy/Procedure

3Therapeutics
09/2012 - 12/2003
1Drug Therapy (Chemotherapy)
03/2006